AH 6809( —— )

Catalog No. M24276 CAS No. 33458-93-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AH 6809
Note

Research use only, not for human use.
Brief Description

AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively).
Description

AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). AH 6809 has a Ki of 350 nM for mouse EP2 receptor.
In Vitro

AH 6809 (1?μM; 30 min) inhibits T. serrulatus venom (TsV)-induced and PGE2-amplified IL-1β and cAMP production in macrophages.AH 6809 (30-300 μM) antagonizes the anti-aggregatory activity of PGD2 in whole blood, with an apparent pA2 of 5.35.
In Vivo

AH 6809 (5 mg/kg; i.p.) decreases TsV-induced mortality, PGE2 and IL-1β production and neutrophil infiltration in the lungs of mice.
Synonyms

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Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

DP|EP1|EP2|EP3
Research Area

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Indication

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CAS Number

33458-93-4
Formula Weight

298.29
Molecular Formula

C17H14O5
Purity

>98% (HPLC)
Solubility

DMSO:25 mg/mL (83.81 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
SMILES

CC(C)Oc(cc1)cc(Oc(cc2)c3cc2C(O)=O)c1C3=O
Chemical Name

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